freckledspeckled 2 points submitted 24 days ago
I canada goose coats on sale did a solo trip from San Diego around the Southwest last October, although I took a route that went south of the Mojave.
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In the Grand Canyon, you can hike the famous Bright Angel Trail and Canada Goose sale be surrounded by people. I’d recommend going with South Kaibab Trail though canada goose uk shop it’s less (but still) populated and incredibly Canada Goose Parka gorgeous. Go early or late in the afternoon to beat some buy canada goose jacket cheap of the heat.
Kat121 227 points submitted 2 months ago
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Even cranky old crab asses need love, and canada goose uk outlet the love of a cat or dog is so uncomplicated. I think that is why it hurts so much when they go. With people, you’ll hold a little of your heart back for safe keeping. With animals you give it all.
SirT6 4,009 points submitted 3 months ago
Just to be clear, canada goose clearance sale OP, tau is not an cheap Canada Goose abnromal protein. Canada Goose Jackets Under normal conditions, tau plays a role in regulating neuronal cytoskeleton. There is a growing body of evidence that tau also has a Canada Goose online pathological form, wherein it becomes hyperphosphorylated and forms neurofibrillary tangles which may be toxic to cells and contribute uk canada goose to Alzheimer disease.
My takeaway from this paper would be that the results are canada goose store part of a body of evidence which largely indicate that tau correlates more strongly than amyloid with neurodegeneration and cognitive decline thecanadagooseoutlet in Alzheimer’s disease.
Does this mean tau neurofibrillary tangles cause AD? Unclear.
Does this mean a drug that targeted neurofibrillary tangles would improve cognition and memory in AD patients? Even more unclear.
One question I have about the methodology is related to the imaging agent they use for PET: 18F AV 1451. What does this target? Presumably some tau isoform? But would it only be reading extracellular tau? My impression was that intracellular tangles were more damaging.
PlasticGirl 15,760 points submitted 5 months ago
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